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Common side effects occurring in more than 5% of patients include: Nausea (affecting up to 30% of patients, particularly during dose escalation) [2] [3] Diarrhea (13–16% incidence) Vomiting (8–10%) Constipation (6–8%) Abdominal pain and dyspepsia Injection site reactions (erythema, pruritus) These gastrointestinal symptoms are typically mild to moderate, transient, and diminish over time as tolerance develops

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Dorsomedial hypothalamus (DMH) and preoptic area (POA) The DMH and POA are a functional complex of nuclei in the hypothalamus, which are involved in the regulation of feeding, drinking, body-weight, and circadian rhythms