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The density of labeled inputs from PPG neurons onto identified CRH and Oxytocin neurons in the PVH was measured in GCG-Cre::SynTom::Lep ob/ob mice and GCG-Cre::SynTom::WT controls by using Imaris image analysis software (Bitplane V9.2, Salisbury Cove, Maine)

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b , Averaged Z-score traces showing dopamine release in the NAc in response to HFD following administration of vehicle or liraglutide in Glp1r S33W mice